Description
HCST, also known as hematopoietic cell signal transducer isoform 1, is a member of the DAP10 family. It can be part of an immunoreceptor complex. This receptor plays an important role in inducing cytotoxicity against MHC class I chain-associated MICA and target cells expressing cell surface ligands such as MICB and UL16-binding protein (ULBP). This receptor complex can play a role in cell survival and proliferation by activation of NK and T cell responses.Recombinant human HCST, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques